The Army are currently on their way to a college in Manchester as armed police close off major roads in the city.
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An army bomb disposal unit is at a college in Trafford, Greater Manchester Police says.
It is too early to say whether the alert is linked to its investigation into the Manchester bomb attack, the force said.
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A college in Trafford, south Manchester, has been evacuated with dozens of police officers, a dog unit and helicopters at the scene.
A number of roads surrounding the college – including Mancunian Way, Limby Street and Jackson Street – have been closed.
Eyewitnesses pictures show a think black cloud of smoke rising from the area.
Greater Manchester Police confirmed the army are responding the the incident.
Helicopter circling moss side and a smoke cloud, central Manchester pic.twitter.com/bProaTyy3V
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